AGAPPE CHITRA MAGNA
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The Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST) has commercially launched Agappe Chitra Magna, a magnetic nanoparticle-based RNA extraction kit it has developed along with Agappe Diagnostics Ltd, a Kochi-based invitro diagnostics manufacturing company
- Chitra Magna is an innovative RNA extraction kit developed by the SCTIMST, the technology for which had been transferred to Agappe Diagnostics last month.
- It uses an innovative technology for isolating RNA using magnetic nanoparticles to capture the RNA from the patient sample and is very sensitive.
- The magnetic nanoparticle beads bind to the viral RNA and, when exposed to a magnetic field, give a highly purified and concentrated RNA.
- As the sensitivity of the detection method is dependent on getting an adequate quantity of viral RNA, this innovation enhances the chances of identifying positive cases.
- The kit, which can be used for RNA extraction for RT-LAMP, RT-qPCR, RT-PCR and other isothermal and PCR-based protocols for the detection of SARS-CoV-2, had been validated by the National Institute of Virology, following which the Central Drugs Standard Control Organisation (CDSCO) had given the go ahead for its commercial production.
- The indigenously developed and manufactured RNA extraction kit would reduce the nation’s dependence on imported kits which are expensive and bring down the cost of COVID-19 testing.
- SARS-COV-2, the causative virus of Covid-19 pandemic, is an RNA virus- a long single-stranded polymeric substance present in all living cells that carries the genetic information of the organism necessary for life.
- One of the critical steps in detecting this virus is by confirming the presence of the RNA of the virus in the sample taken from the throat or nose.
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